【10:00am, May 11, 2010】 Synthetic Polypeptide Materials for Biomedical Applications
Speaker: Prof. Timothy J. Deming
Site: Main Auditorium of ICCAS
8/1989 - 10/1993 University of California Berkeley, CA
Ph.D. in Chemistry, Advisor
Ph.D. thesis research with Dr. Bruce M. Novak
Research encompassing polymer synthesis using organometallic catalysis, elucidation of polymerization mechanisms, and physical properties of helical macromolecules.
9/1985 - 6/1989 University of California Irvine, CA
B.S. in Chemistry.
Undergraduate research with Dr. William J. Evans, 6/1987 - 6/1989.
Research activities involved exploration and expansion of the chemistry of cerium(IV) through synthesis of alkoxide and organometallic complexes.
7/06 – Present Chair, Bioengineering Department, UCLA
7/06 – 1/09 Chair, Biomedical Engineering, Interdepartmental Program, UCLA
7/04 – Present Professor, Bioengineering and Chemistry Departments, UCLA
7/03 - 6/04 Professor, Materials and Chemistry Departments, UCSB
7/99 - 6/03 Associate Professor, Materials and Chemistry Departments, UCSB
2/96 - 6/99 Assistant Professor. Materials and Chemistry Departments, UCSB
3/95 - 1/96 Assistant Professor, Materials Department, UCSB
11/93 - 3/95 Postdoctoral research associate with Professor David A. Tirrell
University of Massachusetts, Amherst, MA
Awards and Honors
IUPAC Macromolecular Division Young Scientist Award 2004
MRS Young Investigator Award 2003
Camille Dreyfus Teacher-Scholar 2000
3M Non-Tenured Faculty Award 1999
Beckman Young Investigator Award 1998-2000
Alfred P. Sloan Research Fellow 1998-2000
National Science Foundation CAREER Award 1997-2001
Office of Naval Research Young Investigator Award 1996-1999
University of California, Regents Junior Faculty Fellow 1996
1. "Nanoscale Double Emulsions Stabilized by Single Component Block Copolypeptides" Hanson, J.A.; Chang, C.; Graves, S.; Li, Z.; Mason, T.G.; and Deming, T.J. Nature, 2008, 455, 85-88.
2. “Polyarginine Segments in Block Copolypeptides Drive Both Vesicular Assembly and Intracellular Delivery” Holowka, E. P.; Sun, V. Z.; Kamei, D. T.; Deming, T. J. Nature Materials, 2007, 6, 52–57.
3. “Charged Polypeptide Vesicles with Controllable Diameter” Holowka, E. P.; Pochan, D. J.; Deming, T. J. J. Am. Chem. Soc. 2005, 127, 12423 - 12428.
4. “Stimuli Responsive Polypeptide Vesicles via Conformation Specific Assembly” Bellomo, E.; Wyrsta, M. D.; Pakstis, L.; Pochan, D. J.; Deming, T. J. Nature Materials, 2004, 3, 244-248.
5. “Rapidly Recovering Hydrogel Scaffolds From Self-Assembling Diblock Copolypeptide Amphiphiles”. Nowak, A. P.; Breedveld, V.; Pakstis, L.; Ozbas, B.; Pine, D. J.; Pochan, D.; Deming, T. J. Nature, 2002, 417, 424-428.
6. "Biomimetic Synthesis of Ordered Silica Structures Mediated by Block Copolypeptides". Cha, J. N.; Stucky, G. D.; Morse, D. E. and Deming, T. J. Nature, 2000, 403, 289-292.
7. "Methylated Mono- and Diethyleneglycol Functionalized Polylysines: Nonionic, Helical, Water Soluble Polypeptides". Yu, M.; Nowak, A. P.; Pochan, D. P. and Deming, T. J. J. Am. Chem. Soc. 1999, 121, 12210-12211.
8. "Facile Synthesis of Block Copolypeptides of Defined Architecture". Deming, T. J. Nature, 1997, 390, 386-389.